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[et_pb_section fb_built=”1″ admin_label=”Overview Section” module_id=”overview” _builder_version=”4.16″ _module_preset=”default” custom_padding=”33px||33px||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ _module_preset=”default” width=”90%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_image src=”https:\/\/d5pharma.com\/wp-content\/uploads\/helix.png” alt=”Helix” title_text=”Helix” align=”center” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” custom_css_main_element=”margin: auto;” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.17.3″ _module_preset=”default” header_2_font=”Roboto||||||||” header_2_font_size=”32px” header_2_line_height=”1.2em” text_orientation=”center” custom_padding=”|||0px||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

\u203a<\/span>\u00a0Meet our lead candidates:<\/h2>\n

MetVax<\/strong><\/span> & PEG:CCS13<\/strong><\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”28px||30px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row make_equal=”on” _builder_version=”4.17.3″ _module_preset=”default” background_color=”#3498DB” border_radii=”on|10px|10px|10px|10px” box_shadow_style=”preset1″ locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.17.3″ _module_preset=”default” header_4_font=”Roboto Condensed||||||||” header_4_font_size=”30px” text_orientation=”center” background_layout=”dark” custom_margin=”|6px|-5px||false|false” custom_padding=”|25px||25px|false|true” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Our patented lead candidates<\/strong>\u00a0have demonstrated benefits in animal models of disease.<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” min_height=”225px” custom_padding=”0px||33px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||2px|||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.17.3″ _module_preset=”default” header_3_font=”Roboto Condensed||||||||” header_3_text_color=”#1C1A1F” header_3_font_size=”30px” header_3_line_height=”1.4em” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

These new candidates<\/strong> comprise DNA or small protein fragments that come with several advantages<\/strong> over conventional biological medicines, such as monoclonal antibodies.<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.17.3″ _module_preset=”default” text_font=”Abel||||||||” text_font_size=”18px” text_line_height=”1.4em” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \n
  • Simple<\/span><\/strong><\/span> synthetic therapeutic molecules.<\/span><\/li>\n
  • Our protein-based vaccines have a new modality<\/strong><\/span><\/span><\/li>\n
  • DNA aptamers are non-immunogenic<\/span><\/strong><\/span>\u2014 ideal for chronic treatment.<\/span><\/li>\n
  • Harnessing the functionality<\/span> of known immune targets.<\/span><\/strong><\/span><\/span><\/span><\/li>\n
  • Proprietary\u00a0platform<\/span><\/strong><\/span> \u2014 a pipeline of DNA- and protein-based molecules for a growing repertoire of targets.<\/span><\/li>\n
  • Vastly less\u00a0costly<\/span><\/strong><\/span> than today’s best biologic medicines.<\/span><\/li>\n<\/ul>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.17.3″ _module_preset=”default” custom_padding=”||3px|||” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.17.3″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_divider module_id=”MetVax” _builder_version=”4.17.3″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”section” module_id=”peg-ccs13″ _builder_version=”4.16″ custom_padding=”0px||||false|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.17.1″ _module_preset=”default” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text module_id=”MetVax” _builder_version=”4.17.3″ _module_preset=”default” text_font=”Abel||||||||” text_text_color=”#1C1A1F” text_font_size=”20px” text_line_height=”1.5em” header_2_font=”Roboto Condensed||||||||” header_2_text_color=”#0C71C3″ header_2_line_height=”1.5em” header_3_font=”Roboto Condensed||||||||” header_3_text_color=”#1C1A1F” header_3_font_size=”24px” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \u203a<\/strong><\/span> Introducing MetVax<\/strong><\/h2>\n

    MetVax<\/span><\/strong> is a carefully defined fragment of the protein cancer biomarker carcinoembryonic antigen (CEA), a molecule involved in the adhesive properties of cancerous cells. CEA influences the cancer cells’ ability to implant in new tissues during the process of metastasis. D5’s scientists have shown that the N-terminal domain of CEA has unique properties that form the basis of MetVax<\/span><\/strong>, a novel cancer vaccine that works by priming the body’s immune response to recognize circulating CEA. The resulting production of antibodies that intervene and prevent the metastatic spread of disease\u2014one of the crucial events that correlate with poor prognosis\u2014has enormous potential to revolutionize patient outcomes.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_margin=”-21px|auto||auto||” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”19px” text_line_height=”1.9em” header_2_font=”Roboto Condensed||||||||” header_2_font_size=”28px” header_2_line_height=”1.2em” text_orientation=”center” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    MetVax<\/strong><\/span> protects against metastasis by a new mechanism<\/span> of immunity.<\/h2>\n

    [\/et_pb_text][et_pb_button button_url=”\/research\/#Vaccines” url_new_window=”on” button_text=”Read More” button_alignment=”center” _builder_version=”4.17.3″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_text_color=”#FFFFFF” button_bg_color=”#3498DB” button_border_color=”RGBA(255,255,255,0)” button_border_radius=”10px” button_font=”Abel||||||||” background_layout=”dark” custom_margin=”-12px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.17.3″ _module_preset=”default” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.17.3″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_divider module_id=”PEG:CCS13″ _builder_version=”4.17.3″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text module_id=”PEG:CCS13″ _builder_version=”4.17.3″ _module_preset=”default” text_font=”Abel||||||||” text_text_color=”#1C1A1F” text_font_size=”20px” text_line_height=”1.5em” header_2_font=”Roboto Condensed||||||||” header_2_text_color=”#0C71C3″ header_2_line_height=”1.5em” header_3_font=”Roboto Condensed||||||||” header_3_text_color=”#1C1A1F” header_3_font_size=”24px” header_3_line_height=”1.2em” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    \u203a<\/strong><\/span> Introducing PEG:CCS13<\/strong><\/h2>\n

    A next-generation DNA aptamer with functional characteristics.<\/h3>\n

    D5Pharma\u2019s lead drug candidate is PEG:CCS13<\/span><\/strong>, a PEGylated single-stranded DNA aptamer that is a selective agonist for the inflammatory modulator, CD200R1, a glycoprotein receptor found on the surface of immune cells. CD200R1 acts as the receptor target for CD200-presenting cells during natural signalling processes that body invokes to dampen the immune response.<\/p>\n

    PEG:CCS13<\/span><\/strong> is a synthetic agonist for this receptor, acting much like an antibody, and enabling immune reactions to be brought under control by a novel mechanism that is distinct from today’s commonly prescribed anti-TNF medicines. As a consequence of D5Pharma’s unique selection approach, PEG:CCS13<\/span><\/strong> is, moreover, a cross-reacting DNA aptamer that selectively recognizes both mouse and human targets, enabling direct bridging from pre-clinical to clinical studies. The addition of the PEGylation, a synthetic modification, allows PEG:CCS13<\/span><\/strong> to be injected and maintained in the circulation for longer and more therapeutically relevant periods of time. This lead candidate has demonstrated efficacy in pre-clinical models of human inflammatory disease.<\/p>\n

    [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” min_height=”180.3px” custom_padding=”1px|||||” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”19px” text_line_height=”1.9em” header_2_font=”Roboto Condensed||||||||” header_2_font_size=”28px” header_2_line_height=”1.2em” text_orientation=”center” custom_margin=”7px|||||” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

    PEG:CCS13<\/strong><\/span> delivers comparable inflammatory control<\/span> to natural protein agonists.<\/h2>\n

    [\/et_pb_text][et_pb_button button_url=”\/research\/#Checkpoints” button_text=”Read More” button_alignment=”center” _builder_version=”4.17.3″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_text_color=”#FFFFFF” button_bg_color=”#3498DB” button_border_color=”RGBA(255,255,255,0)” button_border_radius=”10px” button_font=”Abel||||||||” background_layout=”dark” custom_margin=”-12px|||||” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u203a\u00a0Meet our lead candidates: MetVax & PEG:CCS13Our patented lead candidates\u00a0have demonstrated benefits in animal models of disease.These new candidates comprise DNA or small protein fragments that come with several advantages over conventional biological medicines, such as monoclonal antibodies. Simple synthetic therapeutic molecules. Our protein-based vaccines have a new modality DNA aptamers are non-immunogenic\u2014 ideal for […]<\/p>\n","protected":false},"author":1,"featured_media":104,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","spay_email":"","footnotes":""},"class_list":["post-32","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/pages\/32","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/comments?post=32"}],"version-history":[{"count":21,"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/pages\/32\/revisions"}],"predecessor-version":[{"id":717,"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/pages\/32\/revisions\/717"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/media\/104"}],"wp:attachment":[{"href":"https:\/\/www.d5pharma.com\/wp-json\/wp\/v2\/media?parent=32"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}